Ventricular Expression of tbx5 Inhibits Normal Heart Chamber Development
نویسندگان
چکیده
منابع مشابه
Tbx5 is essential for heart development.
Mutations in the Tbx5 transcription factor cause heart septal defects found in human Holt-Oram Syndrome. The complete extent to which Tbx5 functions in heart development, however, has not been established. Here we show that, in Xenopus embryos, Tbx5 is expressed in the early heart field, posterior to the cardiac homeobox transcription factor, Nkx2.5. During morphogenesis, Tbx5 is expressed thro...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2000
ISSN: 0012-1606
DOI: 10.1006/dbio.2000.9748